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SOX10 is a DNA-binding transcription factor involved in the development of neural crest cells, including melanocytes and Schwann cells [1,2,3,4]. pp 36 tahun 2021 pdf While SOX10 immunohistochemistry (IHC) is often used to help identify tumors of neural crest origin, such as melanocytic neoplasms and peripheral nerve sheath tumors [1, 5,6,7,8,9], SOX10 expression is not entirely specific